Novel Carbon Nanohybrids As Highly Efficient Magnetic Resonance Imaging Contrast Agents

Monday, 25 May 2015: 08:00
Lake Ontario (Hilton Chicago)
B. Sun, R. Cui, H. Huang, and X. Guo (Institute of High Energy Physics)
Gadofullerenes derivatives had been proved to exhibit high relaxivities, even higher than that of commercial Gd-DTPA contrast agents. However, all reported gadofullerene contrast agents were based on the functionalized metallofullerene. In this presentation, we successfully constructed novel water-soluble carbon nanohybrids based on unmodified metallofullerene and graphene oxide, which exhibited high relaxivity and better brightening effect in magnetic resonance (MR) imaging in vivo. Gd@C82 was produced and isolated by the industrial-scale production line of metallofullerenes firstly established in Institute of High Energy Physics, Chinese Academy of Science (CAS). A “secondary spin-electron transfer” relaxation mechanism was proposed to explain how the encaged Gd3+ ions of carbon nanohybrids interact with the surrounding water molecules. This approach opens new opportunities in developing highly efficient and low toxic MRI contrast agent.