ZrO2/GRP Nanocomposite Based Sensor for the Electrochemical Investigation of an Anti-HIV Phytoconstituent Andrographolide

ZrO­₂/graphene (ZrO­₂/GRP) modified glassy carbon electrode was fabricated for the study of electrocatalytic and redox behaviour of anti-HIV phytoconstituent Andrographolide (ADL). The modified electrode reported enhancement in the current values and square wave voltammetry was applied for the study of this herbal drug. Morphological characterization was achieved using scanning electron microscopy, electrochemical impedance spectroscopy and cyclic voltammetry technique. Electrochemical parameters were evaluated at the modified sensor and limits of detection and quantification for the voltammetric determination of ADL was found to be 151.14 ng/mL and 458 ng/mL respectively. ADL was also studied in the blood plasma using ZrO₂/GRP/GCE.