The HPC4Materials program is a new Office of Fossil Energy-sponsored program with participation from the EERE Vehicle Technology Office and the Fuel Cell Technology Office with the aims of introducing industry to High Performance Computing (HPC) for advanced science and engineering simulations, transferring advanced simulation techniques developed at the National Laboratories to industry and developing new materials to promote the energy objectives of the sponsoring offices. Nine partner national laboratories have been working with a variety of large and small companies in a variety of industries. Examples include investigation of corrosion mechanisms in high-temperature, harsh environments and use of machine learning techniques to understand conditions in which fatigue failure might occur in power plant components. Many companies are interested in advanced simulation to reduce costs associated with product/or and process testing. Projects will be highlighted as demonstrations of how HPC can be used to reduce the risk of advanced development.