Lithium-ion battery electrodes are pivotal to attaining high energy and power dense batteries towards vehicle electrification. These electrodes attribute spatial heterogeneity at different scales (particle, pore, electrode) stemming from the electrode processing steps. Particularly, the inhomogeneity in the negative electrode can be ascribed to the spatial variation of active material (graphite) and the polymeric binder. The inherent inhomogeneity at different scales can translate to non-uniform kinetic and transport resistance. These effects can foster higher over-potentials, restraint ionic transport with localized potential drop and heat generation. The localized heterogeneity coupled with anode centric degradation behavior can also facilitate preferential lithium plating. This study elucidates the mesoscale implications of the electrode-scale heterogeneity on the coupled thermo-electrochemical response in terms of performance and degradation.