The U.S. Department of Energy (DOE) is supporting a wide range of research and development efforts that fall under the umbrella of low temperature electrolysis (LTE). These efforts range from early stage R&D on cell components to demonstrating the effectiveness of integrating MW-scale electrolyzer systems with the electric grid to provide ancillary services. LTE is included in multiple initiatives led by the Fuel Cell Technologies Office (FCTO) at DOE’s Office of Energy Efficiency and Renewable Energy (EERE). Low temperature electrolysis is one of four pathways being supported under DOE’s HydroGEN Energy Materials Network (EMN) Consortium on Advanced Water Splitting Materials (AWSM) for H₂ production. The HydroGEN EMN offers an extensive collection of materials research capabilities at 6 core national laboratories for addressing AWSM R&D challenges in efficiency, durability, and cost. The LTE work supported under HydroGEN includes early stage R&D in membranes and catalysts for both PEM and AEM electrolysis. Low temperature electrolysis also has a role in DOE’s H2@Scale energy system vision. This initiative is bringing together diverse stakeholders to advance affordable wide-scale hydrogen production, transport, storage, and utilization to unlock revenue potential and value across multiple sectors. The use of low-cost electricity to affordably split water into hydrogen and oxygen is central to implementation of the H2@Scale concept. Work is also being carried out on electrolyzer manufacturing, benchmarking, protocol development, and technoeconomic analysis. An overview of FCTO-supported activities related to these initiatives and topics, and the role of LTE in them, will be provided.