Due to depletion of fossil fuel and global warming caused primarily by carbon dioxide and other greenhouse gases from produced from burning of fossil fuels, water splitting has been researched as a viable, sustainable, efficient energy conversion and zero emission alternative. Many materials based on transition metal chalcogenides have been reported for water splitting as Oxidation Evolution Reaction (OER), Hydrogen Evolution Reaction (HER) and Oxygen Reduction Reaction (ORR) and some as bifunctional electro-catalysts due to their high activity and low cost. Since decreasing electronegativity of chalcogens in transition metal chalcogenides, increases covalency in the transition metal-chalcogen bond, altering the electronic band structure of the material and subsequently lowering the oxidation potential, while increasing the susceptibility of the catalyst towards corrosion. In this work, we investigated the effect of mixed anion chalcogenides by systematically replacing some composition of the chalcogen in transition metal chalcogenides with a different chalcogen on cobalt telluro-selenide (Co_x-Te_y-Se_z) and nickel telluro-selenide (Ni_x-Te_y-Se_z) series for OER, HER and ORR activity. The electrocatalytic properties of these materials were explored using various electrochemical techniques, such as, linear sweep voltammetry (LSV), cyclic voltammetry (CV), chronoamperometry, and Electrochemical Impedance Spectroscopy (EIS), as well as and Tafel slope and electrochemical surface area estimations, under basic condition. It was observed that the telluro-selenides showed high electrocatalytic activity for OER, which were higher than the selenide but lower than the telluride confirming that increasing anion electronegativity decreased catalytic activity for OER. They were also found to be active towards both HER and ORR. Our results indicate that there is a systematic trend in their activity due to covalency and electronic band gap/structure interplay in the transition metal mixed anionic chalcogenide. A systematic study of the chemistry of these materials, their detailed characterization with powder X-ray diffraction, scanning and transmission electron microscopy, Raman, and X-ray photoelectron spectroscopy, and OER, HER as well as ORR catalytic efficiencies will discussed.