Interest in advanced anion exchange membrane (AEM)-based electrolyzers is growing because of their ability to produce hydrogen using platinum group metal-free catalysts, less expensive anode flow fields, and bipolar plates. Quaternized ionomeric binders play a critical role in AEM electrolyzers in their performance. This presentation will focus on the ionomer design aspects of AEM-based electrolyzers. The performance of AEM-based electrolyzers will be demonstrated using several homemade ionomers to identify the performance-limiting factors. Then, I will discuss the chemical structural impact of ionomers in hydrogen and oxygen evolution reactions. The purpose of this presentation is to provide direction for long-lasting electrolyzers with highly efficient hydrogen production capabilities.