Fullerenes and endohedral metallofullerenes (EMFs) are molecular building blocks for a variety of organic materials widely applicable in photovoltaics, catalysis, quantum information science, semi-conductors, biomedicines, and so on. Regioselective functionalization reactions are essential for the construction of fullerene and EMF materials. Multicomponent reactions that generate reactive species to be captured by the double bonds on fullerenes or EMFs represent a useful approach to develop new reactions. In this presentation we hope to share our recent work in the development of new reactions for fullerene and EMF functionalizations, including isocyanide-induced reactions, reverse electron demand Diels-Alder reactions, and aminations.