Redox flow batteries are increasingly recognized as a promising candidate for large-scale grid energy storage due to their unique architecture that decouples the power and energy. This feature is desirable for long-duration energy storage since it enables the flow batteries to singularly increase the duration without the concomitant cost increase of the power component. This presentation will give an overview of the current research and development of the redox flow battery technologies, especially considering their manufacturing challenges from material synthesis, electrolyte formulation, cell components, and devices to the systems. Focuses will be given to developing organic redox-active molecules, new testing technics, testing protocols, and procedures. A data-driven flow battery research, development, and deployment platform, a digital twin flow battery, will also be discussed.