Self-powered systems for biosensing have attracted tremendous research interest in recent years, mainly due to the rapidly expanding market of wearable and portable devices for applications in clinical diagnosis and physiological monitoring. In our work, novel and unique hierarchical nanostructures were designed and synthesized to realize electrochemical devices with high performance, especially the sensor stability and energy storage capability. Meanwhile, scalable and printable approach was developed to integrate these electrochemical devices into monolithically integrated self-powered systems. The as-developed nanostructured electrochemical devices in conjunction with printable approach show great potency in fabrication of various wearable integrated self-powered devices for personalized healthcare monitoring applications. Our research highlights are as follow:

1. Development of nanoporous membranes for electrochemical sensor applications. It eliminates enzymes escaping and provides sufficient surface area for molecular/ion diffusion and interactions, so as to ensure the sustainable catalytic activities of the sensors and generate reliable measurable signals during noninvasive monitoring. The highly improved stability of sensors is extremely desirable for investigation of metabolic activities in physiological systems.
2. A fully integrated and self-powered system in a smartwatch fashion for continuous monitoring of sweat glucose levels during both equilibrium status and dynamic activities. The smartwatch can be self-powered by flexible photovoltaic cells, without external charging, the harvested energy can also be stored in the flexible Zn-MnO₂ batteries as backup power source. It is also capable for real-time and in situ data analysis/display with integrated circuit board and E-ink screen.
3. A monolithically integrated self-powered smart sensor system with energy supplied by fully printable planar supercapacitors and embedded solar cells, was fabricated on plastic substrate with inkjet printing technique as a proof-of-concept. The as-developed printable nanostructured electrochemical devices in conjunction with printable approach for system integration show great potency in fabrication of various wearable integrated self-powered devices for personalized healthcare monitoring applications.