Multiplexed Electrochemical Device for the Detection of Biomarkers of Parkinson’s Disease Using 3D Printing

Monday, 10 October 2022: 15:20
Room 312 (The Hilton Atlanta)
N. H. B. Ho, D. L. Glasco, and J. G. Bell (Washington State University)
Neurotransmitters are chemical messengers that carry signals between cells. Imbalances in neurotransmitter levels have been linked to physical, psychotic, and neurodegenerative diseases such as Alzheimer's, Parkinson's, dementia, addiction, depression, and schizophrenia. Therefore, the rapid detection of neurotransmitters such as dopamine, acetylcholine, glutamate, serotine, and norepinephrine are essential for early diagnosis of various neurological disorders. This talk will focus on the development of a multiplexed electrochemical device using 3D printing for the simultaneous detection of biomarkers related to Parkinson’s disease. By combining the capabilities of stereolithographic (SLA) and fused-deposition modelling (FDM) 3D printing, we demonstrate the ability to fabricate and integrate potentiometric and voltametric sensors into the device. Importantly, we show that this approach is highly modifiable and scalable, providing a pathway towards the development of a full-panel diagnostic test for neurological disorders.