Protonic ceramic electrochemical cells (PCECs) hold the promise for hydrogen production as well as flexible chemical manufacturing by in-situ hydrogen/proton use at intermediate temperatures (400-600^oC). As the technology is emerging and fast growing, the production and manufacturing of 5x5 cm² PCECs represent a key step to link the fundamental study on the academic-based button cells (e.g., 10 mm to 1 inch) to the higher technology readiness level (TRL) development with the industry standard unit (> 10x10 cm²) for the stack assembly. At Idaho National Laboratory, we developed the advanced manufacturing technologies and applied our knowledge and experience in materials science and engineering for such a transition. Significant advancement is achieved by integrating the materials, structure and interface engineering R&D into cell fabrication and manufacturing with the guidance of the quality assurance and quality control (QA&QC) system .to achieve reliable, repeatable, and durable performance for PCECs.