The over prescribing of broad-spectrum antibiotics has given rise to the multidrug resistance in bacteria. The antimicrobial resistance caused the medicines and treatments to become ineffective and became difficult to treat infection. In order to avoid the overuse of antibiotics, antibacterial material have been developed and applied in preventing bacterial infection, drug delivery, and medical implant.

Nanomaterials materials show great potential in many applications [1-33]. Therefore, in our study, we designed nanosilica islands on graphene oxide template to disperse the silver nanoparticles and improve its antibacterial properties. Silver nanoparticles have been known for its exceptional antimicrobial properties. However, some bacteria were able to use their flagellum to cause the silver nanoparticles agglomerated. By using silica nanoparticles and graphene oxide, we not only avoid the agglomerated issues but also improve the antibacterial ability of the material.

Our novel composite was characterized by using Powder X-Ray Diffraction (P-XRD), Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), Tranmission electron microscopy (TEM), and Fourier Transform Infrared (FTIR). The silica nanoparticles and graphene template helped to form dispersed nanoparticles of 7 nm. The composite successfully eliminated 99.99% of Escherichia coli and Bacillus Subtilis within one hour.

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