The demand for high energy and power density of Lithium-ion batteries due to increasing acceptance into mobility and transportation sector has pushed wide spectrum of developments from materials to processing/packaging technologies. The design considerations at the cell level are primarily the performance and safety aspects as the batteries could degrade over cycle life in capacity or could lead to thermal runaway under extreme operating conditions. To understand the implications of any new development a comprehensive predictive modeling framework is developed that could model multiple spatial/temporal scales and could seamlessly integrate multiple physics. In this poster we introduce a new release of virtual integrated battery environment (vibe) that model variations of electrode materials and associated physical processes within full length cell simulations. As a demonstration, couple of electrochemical-thermal-mechanical simulationsbased on the upscaled properties are presented that help us understand the underlying mechanisms that battery undergoes during extreme conditions.