Enantioanalysis of S-Ketoprofen Using Potentiometric and SPR Sensors

Tuesday, May 13, 2014: 17:00
Sarasota, Ground Level (Hilton Orlando Bonnet Creek)
R. I. Stefan-van Staden, J. F. VAN Staden (Laboratory of Electrochemistry and PATLAB Bucharest, National Institute of Research for Electrochemistry and Condensed Matter), R. G. Bokretsion (University of Illinois at Chicago), and H. Y. Aboul-Enein (Pharmaceutical and Medicinal Chemistry Department, The Pharmaceutical and Drug Industries Research Division, National Research Centre)
Ten enantioselective, potentiometric and SPR sensors based on carbon paste and gold impregnated with alpha-, betta-, carboxymethyl-betta-(as sodium salt), 2-hydroxyl-3-trimethylammoniopropyl -betta-(as chloride salt) and gamma-cyclodextrins, were proposed as a chiral selectors for assay of S-ketoprofen raw materials and in its pharmaceutical formulation Ketoflam capsule. The best response was obtained when betta-cyclodextrin was used for the electrode design. The sensors showed very low detection limits (of 10-8 to 10-9 magnitude orders). Stability constants values were also recorded for the interaction between S-ketoprofen and chiral selectors using SPR method.

Acknowledgements This work was supported by UEFISCDI PNII Program Ideas 2011-2014, Contract nr. 123/05.10.2011 and by ERC-like-3/07.2012 program.