Synthesis of Biologically Relevant Compounds Catalyzed By Metal Porphyrin Complexes
Herein we report the use of ruthenium porphyrins to promote the synthesis of biologically interesting compounds such us: a) α- and β-amino ester by amination of benzylic C−H bonds. The methodology was also effective in synthesizing two derivatives of methyl L-3-phenyllactate in order to convert one of them into the corresponding β-lactam;3 b) dihydrophenanthridines and phenanthridines, important core structures in a large class of pharmaceutical compounds, through the intramolecular amination of several 2-azido biaryls;4 c) C3-functionalized indoles by an intermolecular reaction of aryl azides with alkynes. Several derivatives were synthesized with yields up to 95%, high regioselectivity, and without requiring the time consuming prefunctionalization of reagents and the addition of oxidants and/or additives.5
In addition, we describe the catalytic activity of glicoporphyrin derivatives in amination reactions. It is worth noting that the use of these catalytic materials with very low toxicity could enhance the eco-sustainability of the entire synthetic process.
 a) S. Cenini, E. Gallo, A. Caselli, F. Ragaini, S. Fantauzzi, C. Piangiolino Coord. Chem. Rev. 2006, 250, 1234; b) D. Intrieri, P. Zardi, A. Caselli, E. Gallo Chem. Commun., 2014, 50, 11440.  S. Fantauzzi, A. Caselli, E. Gallo Dalton Trans, 2009, 5434.  P. Zardi, A. Caselli, P. Macchi, F. Ferretti, E. Gallo Organometallics 2014, 33, 2210.  D. Intrieri, M. Mariani, A. Caselli, F. Ragaini, E. Gallo Chem. Eur. J. 2012, 18, 10487.  P. Zardi, A. Savoldelli, D. M. Carminati, A. Caselli, F. Ragaini, E. Gallo ACS Catal. 2014, 4, 3820.