A Graphene-Zinc Nanorods Nano-Composite Film Sensor for Sensitive Determination of Tizanidine in Solubilized System
A novel graphene/zinc nanorods nano-composite modified glassy carbon electrode (GR/ZnRs/GCE) based electrochemical sensor has been developed for the sensitive determination of a muscle relaxant drug tizanidine (TZ) in a solubilized system of cetyltrimethyl ammonium bromide (CTAB). The developed sensor was characterized by scanning electron microscopy, electrochemical impedance spectroscopy and cyclic voltammetry. It was found that the nanocomposite film of GR/ZnRs on GCE exhibits excellent electrocatalytic activity towards tizanidine reduction in britton robinson buffer at pH 6.5. Addition of CTAB to the solution containing drug enhanced the peak current and also lowers the reduction overpotential. Various kinetic parameters affecting the monitored electrocatalytic response were investigated and optimized for tizanidine determination. Under optimized conditions the developed sensor shows linear response over the concentration range of 1 ng mL-1 to 10 µg mL-1. The applicability of proposed sensor is further extended to in vitro determination of the drug in pharmaceutical formulation with an acceptable recovery from 99.63% to 100.98%. The fabricated (GR/ZnRs/GCE) sensor holds great promise for simple and sensitive quantification of tizanidine using electroanalytical techniques.
Keywords: Tizanidine (TZ), Graphene/Zinc nanorods modified glassy carbon electrode (GR/ZnRs/GCE), CTAB, Voltammetry.