Functionalization of the Corrole Ring: A Neverending Game
From this point of view, it has been important to study the possible synthetic modifications of the corrole framework, with the aim to tune the properties of the resulting macrocycle to the corresponding application.
Although the impressive progress of the corrole preprative chemistry, the functionalization of this macrocycle is still a challenging research area.
We have contributed to this area by studying the definition of synthetic protocols for the insertion of different substituents, both into the meso and b-positions of the macrocycle, with the aim of building more complex structures.
In these reaction, corrole has demonstrated a peculiar regioselectivity, with the substituents introduced in the directly linked pyrroles A and D. However we have recently observed that the substitution pattern can be modulated by the different substituents introduced in the peripheral positions.
In the present work we summarise our recent achievements in the functionalization of the corrole ring.