Fullerene Biomaterials for PDT or MRI: Effects of Derivatization on Activities

Wednesday, October 14, 2015: 08:20
Borein B (Hyatt Regency)
Y. Yamakoshi (ETH Zuerich), E. G. V. Tiu (ETH Zürich), and S. Aroua (ETH Zürich)
Fullerene-based water-soluble materials have been considered as seed compounds for photosensitizers in photodynamic therapy (PDT) and contract reagents in magnetic resonance imaging1 (MRI). We have been working on the development of new biocompatible fullerene (C60, C70 and Gd3N@C802) materials by complexation with or by covalent attachment of water-soluble polymers such as poly(vinylpyrrolidone) (PVP) and polyethylene glycol (PEG). Initial studies on the C60/ or C70/PVP complex provided sufficient water-solubility and efficient generation of superoxide (O2).3  But a subsequent study on C60-PVP or C70-PVP copolymers (uncontrolled) resulted in slightly better water-solubility provided and improved generation of 1O2.  It appears that bioactivity of the C60 or C70 is different due to the formation of water-soluble materials in aqueous medias.  In this study, we discuss on the effect of derivatization of fullerene cores on the bioactivities including reactive oxygen species generation from bis-, tris-adducts of C60 and M3N@C80 (Figure) and well-defined fullerene-PVP copolymers that we have recently prepared5 using Prato reactions.6

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