Wearable chemical sensor technologies enable the opportunity to continuously collect physiologically information on an individual’s health status. This is in contrast to traditional blood draws and subsequent analysis. Using glucose oxidase as a model enzyme we compare several fabrication methods and describe an optimized glucose monitoring sensor which works in open circuit potential with good selectivity and sensitivity over a glucose concentration range of 50 to 300 µM (Figure 1). The sensors maintain good sensitivity of more than 2000 nA/mM after two weeks. The current drifting is minimal and reproducible and device can be made. (Figure 1c). Key steps, procedural details, and findings will be discussed in this work.

Figure 1. (a) The open circuit potential amperometric monitoring the liberated hydrogen peroxide after (a) 1 day of fabrication and (b) 15 days of fabrication; along with the calibration curves on inset. (c) Drifting and calibration curve obtained for sensors made from different batches.