Recent theoretical studies predicted that the magnetic properties of Dy₂O@C₈₂ may be superior than any other clusterfullerenes decovered so far, but the synthesis and characterization have never been reported. Here, we report that the clusterfullerenes Dy₂O@C₈₂ have been synthesized by arc-discharging method with graphite rods packed with graphite powder and metal oxide(Dy₂O₃) under a He/CO₂(8:1) atmosphere. Two isomers of Dy₂O@C₈₂ endohedral fullerene have been isolated and purified by high performance liquid chromatography by multistage separation on different columns. The purified Dy₂O@C₈₂ were characterized by mass spectrometry, UV-Vis-NIR absorption spectroscopy. One isomer shows large resemblance to those of previously reported metallic fullerenes, such as Er₂@C_s-C₈₂, Sc₂O@C_s-C₈₂, and another one is similar to Y₂C₂@C_3v-C₈₂. This work will lead to the detailed study of the unique molecule magnetic properties of dysprosium-based oxide cluster fullerenes and their potential of application in high density information storage, quantum calculation and spintronics.