Recently, many of skin-like or wearable health monitoring sensors have been developed for our convenience. However, most of them still need the wired connector for power and data transmissions. To make fully wireless sensors, the near-field communication technology has been used for wireless communication. The work reported here materials and mechanics ideas for wireless optoelectronic systems that adopt skin-like formats for monitoring the properties of the optical properties the skin and the surrounding environment. Wireless operation of multiplexed arrays of miniaturized, multicolored light emitting diodes couples with digital photodetection and near field communication (NFC) to allow spectroscopic characterization of the skin, in modes compatible with NFC-enabled devices, such as smartphones and tablet computers. Examples in quantitative measurement temporal dynamics of arterial blood flow, blood oxygenation, ultraviolet dosimetry as well as four-color spectroscopic evaluation of the skin demonstrate the versatility of these concepts. The results establish an wireless communication technology platform for optical assessment, suitable use on nearly any region of the body, relevant for clinical care and at-home diagnostics alike.