Lithium-ion batteries (LIBs) have found widespread usage in small scale electronics and are slowly inching towards large scale applications like electric vehicles and grid storage. The acceptance of LIBs for these applications is predicated on mitigation of performance and safety issues intrinsic with application at varying operating conditions. Performance and safety degradation of LIBs with cycling is attributed to electrode pulverization coupled with solid electrolyte interphase (SEI) formation and Li plating on the anode surface. Extreme operating conditions (e.g. low temperature and high current rates) can exacerbate Li plating phenomena at the anode. Consequently, it is essential to delineate the effects of coupled mechanical (fracture) and electrochemical (SEI, plating) degradation modes in lithium ion batteries. In this work, we focus on investigating these coupled mechano-electrochemical interactions, based on stochastic analysis and modeling to elucidate the interplay between the trifecta of degradation modes, with the representative particle-electrolyte domain under investigation shown below.