High-entropy alloys (HEAs) have recently aroused increasing research enthusiasm due to their attractive properties, such as easy formation of nano-size precipitates, high hardness, good fatigue with fracture resistance, good thermal stability, excellent corrosion resistance and tendency to form simple solid solutions with face-centered cubic (FCC) and body-centered cubic (BCC) crystal structure. However, to the best of our knowledge, the growth of HEAs nanostructures and its electrocatalytic properties have not yet been reported. Herein, we demonstrate for the first time, HEAs nanorod arrays on stainless steel by glancing angle deposition system (GLAD) as electrocatalysts for oxygen evolution reaction (OER). This electrocatalysts exhibited excellent OER activity and durability. Specifically, a low overpotential of 302 mV can be achieved at a current density of 10 mA cm⁻², yielding a Tafel slope of ~28 mV dec^-1 in 1 M KOH. Moreover, it can be operated more than 500 cycles of a linear voltammetry (LSV) scan at a scan rate of 5 mV/s. The outstanding performances is attributed to the high surface area of nanorod arrays. This work opens up new great potential in the field of energy based application such as batteries, supercapacitors, and electrocatalytic applications.