In this talk, Dr. Yeo will discuss the fundamental study in soft materials, flexible mechanics, nanomanufacturing, machine learning, and system packaging to develop nanomembrane-based intelligent soft wearable biosensors and bioelectronics. He will also talk about how fundamental science and knowledge can be applied to create various types of wearable soft sensors, circuits, and integrated bioelectronics. Afterward, he will share application examples of the wearable soft system as a portable health monitoring device, disease diagnostic device, therapeutic system, and human-machine interface system. Details of a device design, manufacturing, optimization, signal processing, and classification will be shared at high levels.