Electrochemistry characterization of organic compounds is a topic of great interest, due to electron transfer process is related with important biological process. The voltamperometry cyclic is an accurate technique to evaluate the redox process in antiepileptic drugs. Research groups have reported the synthesis of multivalent compounds that increase pharmacological response, in comparison with monovalent pharmacophores.1-3
In this work we synthetized divalent sedative drugs type: o-aminobenzamides (OAB) and 2,4-quinazolinendiones (QZD); these alkaloids present biological properties such as, antipsychotics and anticonvulsants, these properties can be evaluated through electron transfer capacity.
The results show the electrochemical small library of six compounds that was prepared using the OAB and QZD structures as pharmacophores, with ethylene and polyethylene glycol, as bridge. Electrochemistry studies were performed to determine the redox potentials of the compounds with different electrodes Pt, Au and vitreo carbon. These tests gave relevant information to attribute the electron transfer capability of these structures, being Pt electrode the one that gave more information of redox in the OAB and QZD compounds.
- Kovacic, R. Somanathan, M. Inzunza. Rev. Chem. Soc. 47(2003), 146.
- A. Rivero, K.A. Espinoza, R. Somanathan, Molecules, 9(2004), 609.
- R. Ames, P. Kovacic, K. P. Kadaba, F.P Kiser, Epilepsia, 33(1992), 936.
