Exciting new advances in materials engineering and biological catalysis are making it possible to make high-precision electrochemical measurements at the molecular level. Translating these advances to practical agricultural and biological diagnostics in the field requires portable potentiostat devices with performance rivaling those of expensive benchtop systems. In recent years several open-source potentiostat designs have been made to make biological experimentation more accessible. Here we report on a palm-sized open-source hardware design (ABE-Stat) that interfaces wirelessly through Bluetooth and/or WiFi. A fully operational interface is available for free for Android devices, which includes functionality for cyclic voltammetry, differential pulse voltammetry, chronoamperometry, electrochemical impedance spectroscopy, and measurement of open circuit potential, in 2 or 3 electrode configurations, and language support for English, Spanish, Portuguese, Japanese, Korean, and Chinese. Static current noise is within an order of magnitude of 24-bit resolution measurements, and dynamic precision of applied dynamic potentials is approximately equivalent to the 16 bit resolution of the signal source. The hardware can easily be reprogrammed for other dedicated analytical functionality, including operation in networked industrial environments through WiFi. We anticipate that the availability of this design will help accelerate the commercialization of new electrochemical diagnostic technologies.