In this talk, I will summarize the recent research on synthesis, characterization and applications of two-dimensional nanomaterials in my group. I will introduce the synthesis and characterization of novel low-dimensional nanomaterials, such as graphene, transition metal dichalcogenide nanosheets and other 2D nanomaterials. Then I will demonstrate the applications of these novel 2D nanomaterials in chemical and bio-sensors, solar cells, hydrogen evolution reaction, electric devices, memory devices, conductive electrodes, etc.