Lithium-ion batteries are lightweight power sources with high recuperation capability, which could be a potent battery technology for emerging low-voltage hybrid markets. Based on lithium-ion battery technology, automotive manufacturers have investigated various 12V and 48V systems with different dimension and performance requirements. Depending on their needs for a pack location and system design, OEMs’ interest in cell chemistry varies from conventional carbonaceous anode-based battery to LTO anode-based one to LFP cathode-based one. In this talk, current lithium-ion battery solutions to various low-voltage needs will be discussed with a focus on technical challenges in cell design. Also, we will explore future lithium-ion battery technology required for 12V and 48V lithium-ion batteries.