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Novel Carbon Based Electrochemical C-Reactive Protein Biosensor
C-Reactive Protein (CRP), found in blood serum has been proven to show a direct correlation to the inflammation of arteries and likelihood of myocardial infarction (MOI) and cardiovascular disease (CVD). Conventionally, CRP is quantified at a third-party laboratory using Enzyme-Linked Immunosorbent Assay (ELISA). A point-of-care, accurate, and cheaper diagnosis technique could allow for rapid CRP detection and reduce health care cost.
Biosensors have been fabricated in attempts to meet diagnoses requirements. Biosensors belong to a class of diagnostic devices that play a significant role in unique detection and measurement of various biomarkers. In order to obtain a CRP biosensor with the necessary sensitivity and selectivity, a nanohybride material with unique catalyst system has been proposed.
The nanohybride material integrates carbon nanotubes (CNT) and metallic nano-particle catalysts. The carbon based material has an enhanced surface area that allows for excellent electrochemical biosensor performance. Immobilization of a CRP reactive enzyme provides for the needed CRP selectivity. These engineered CNT based electrodes have shown excellent sensitivity and detection of CRP as low as 0.025 mg/L.