In this study, electrochemical degradation of the widely used antibiotic Ciprofloxacin (CIP) was investigated using commercial mixed metal oxide anodes (RuO₂/IrO₂/TaO₂ coated Ti- mesh). Here, one of the secondary inorganic by-products namely, Fluoride ions (F^-), was removed from the aqueous medium by means of an adsorption process using Fe₂O₃/HAp nano composites. A general hydrothermal process was used to prepare Fe₃O₄ nanoparticles dispersed on the hydroxyapatite nano rods. The obtained nano composites were characterized by XRD, FESEM, BET, VSM and FTIR analysis. The synthesized Fe₃O₄/HAp Nano composites were further explored to study the maximum removal of F- (99.9%) by optimizing various conditions. The effects of the oxidative potential, current density, initial concentration of CIP, electrolysis time, electrolyte concentration and initial pH on the formation and evolution of F^- ions released to the medium during the process were evaluated. The degradation efficiency of CIP was further confirmed by HPLC and GC-MS analysis. At the optimum conditions (current density = 5 mA/cm², initial CIP concentration = 5mg/L, pH = 3.4, electrode gap = 1.5 cm, and electrolyte concentration = 0.1M Na₂SO₄), after 30 min, the removals of CIP concentration, COD and TOC were about 99.9%, 75.4%, and 85.6%, respectively. The reaction exhibited a pseudo first-order kinetics model. The results showed that combined electrochemical oxidation, using a RuO₂/IrO₂/TaO₂ coated Ti-mesh as anodes along with adsorption, using adsorbent Fe₂O₃/n-Hap composites were highly effective for the degradation of CIP.