PARC and UCSD are developing a flexible hybrid biosensor platform to enable continuous remote monitoring of bioanalyte concentrations in saliva. The electrochemical sensor system will be fabricated on a small, flexible plastic foil for mounting on a mouth guard, and enable continuous sensing of lactate, glucose, or other analytes. Chronoamperometry based on enzymatic oxidation of target species has been demonstrated to have high sensitivity and capability for quantification of analyte concentrations. Saliva is favorable for biosensing because of its accessibility and the correlation with blood concentrations of important analytes. The goal of the current work is to demonstrate a manufacturable, reliable sensor system. To this end, the electronics will be fully encapsulated and include wireless charging and readout, with easily removable and replaceable printed electrodes. Here, we will present an overview of the system and discuss current progress.