The growing need for large lithium batteries and lithium battery powered equipment aboard submarines provides major challenges to the US Navy; two of these challenges include (1) early battery casualty detection and (2) containment or mitigation of hazards associated from lithium-based battery casualties. Lithium ion rechargeable batteries used within research unmanned undersea vehicles (UUV) was abusively tested inside of its vehicle and was instrumented with water mitigation and various types of presumptive pre/post casualty onset detection sensors. These efforts were conducted under the requirements for the Navy’s Lithium Battery Safety Program, Naval Sea Systems Command Instruction 9310.1C and related documents as guidance for need. This effort followed similar recent works for the storage and carriage of large form lithium and lithium-ion batteries conducted preciously. This paper will review the results of these tests conducted by the Naval Surface Warfare Center, Carderock Division (NSWCCD), Naval Undersea Warfare Center, Newport (NUWC NWPT) and the Naval Research Center (NRL) over the past six years. These efforts have enabled the carriage and deployment of lithium battery powered systems from surface platforms and are expected to enable the deployment from undersea platforms.