Carbon-fiber microelectrodes have been used for decades for real-time, in vivo measurements of neurotransmitters. However, they require hand fabrication, are difficult to make reproducibly, and have geometries that are limited by the material shape. Our lab is seeking to enhance microelectrode fabrication by designing new strategies for batch fabrication. One strategy is 3D printed molds, that any electrode material (including carbon fibers or CNT yarns) can be laid in and made into an electrode and coated with polyimide. Another strategy is to grow carbon on the inside of quartz nanopipettes to batch fabricate small diameter electrodes. These fabrication strategies, combined with new carbon nanomaterials, will enhance the detection of neurotransmitters in vivo.