Highly Selective Detection of Glucose, Cholesterol and Urea with Integrated ZnO Nanorods Field-Effect Transistors Array Biosensors

Tuesday, October 13, 2015: 16:00
106-C (Phoenix Convention Center)
R. Ahmad, J. H. Park (Chonbuk National University), and Y. B. Hahn (Chonbuk National University)
Nanotechnology revolution has led to the nanofabrication of sensor devices for rapid and specific identification of chemical/biological species. However, the development of multiplexed nanoscale biosensor for simultaneous detection of different analytes still remains a major challenge at the nanotechnology frontier. It is well recognized that diabetes mellitus is a metabolic disorder resulting in an abnormal blood glucose level and activation of several metabolic pathways related to inflammation and apoptosis events. We have developed ZnO nanorods (NRs) based, integrated field-effect transistors (i-FETs) array biosensor with simultaneously immobilizing GOx, ChOx and Ur enzymes on three different ZnO NRs arrays. In this lecture, we reoprt a novel straightforward approach for simultaneous and highly selective detection of multi-alanytes (i.e., glucose, cholesterol and urea) with the i-FETs array biosensor without interference in each sensor response. Compared to analytically measured data, performance of the i-FETs array biosensor is found to be highly reliable for rapid detection of multi-analytes in mice blood, serum and blood smaples of diabetic dogs. The development of an integrated, low-cost ZnO NRs i-FETs array biosensor will produce quick detection under critical patient conditions, early identification of disease/disorder, and also have an enormous impact on the future generations.