An extremely electro-active polymer nanocomposite material of polypyrrole and titanium dioxide (Ppyl/TiO₂) has been synthesized from pyrrole and titanium dioxide using interfacial polymerization method. The synthesized nanocomposite was used as a voltammetric sensor (Ppyl/TiO₂/GCE) by modifying glassy carbon electrode (GCE) for the quantification of sulfamoxole (SLM). The synthetic nanocomposite material before modification was characterized by various spectral techniques like infrared (IR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Moreover the developed sensor was also characterized by electrochemical impedance spectroscopy and various voltammetric techniques. The developed Ppyl/TiO₂/GCE sensor showed an excellent electroanalytical performance than the electrodes i.e., Ppyl/GCE, TiO₂/GCE and bare GCE. The constructed sensor under optimized experimental procedure showed the linear response for the oxidation of SLM over a concentration range from 1.25μgmL⁻¹ to 12.50μg mL⁻¹ having correlation coefficient of 0.9980 (r²) with 1.24 µg mL⁻¹ limit of detection and 4.15 µg mL^-1 limit of quantification. The sensor exhibited the superb sensitivity for the detection of (SLM) with reproducibility of 3.19% relative standard deviation (RSD). The proposed method was further effectively applied for the analysis of SLM in pharmaceutical formulation with a recovery of 99.50 % to 100.73 %.

KEYWORDS: Nanocomposite, Sulfamoxole, Polypyrrole, Glassy Carbon Electrode, Voltammetric Sensor.