Synthetic Polypyrrole/Titanium Dioxide (Ppyl/TiO2) Nanocomposite As Potential Electroactive Material for the Voltammetric Quantification of Sulfamoxole

Tuesday, 30 May 2017
Grand Ballroom (Hilton New Orleans Riverside)
A. L. Khan (School of Studies in Chemistry Jiwaji University Gwalior) and R. Jain (Jiwaji University,Gwalior,India)
An extremely electro-active polymer nanocomposite material of polypyrrole and titanium dioxide (Ppyl/TiO2) has been synthesized from pyrrole and titanium dioxide using interfacial polymerization method. The synthesized nanocomposite was used as a voltammetric sensor (Ppyl/TiO2/GCE) by modifying glassy carbon electrode (GCE) for the quantification of sulfamoxole (SLM). The synthetic nanocomposite material before modification was characterized by various spectral techniques like infrared (IR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Moreover the developed sensor was also characterized by electrochemical impedance spectroscopy and various voltammetric techniques. The developed Ppyl/TiO2/GCE sensor showed an excellent electroanalytical performance than the electrodes i.e., Ppyl/GCE, TiO2/GCE and bare GCE. The constructed sensor under optimized experimental procedure showed the linear response for the oxidation of SLM over a concentration range from 1.25μgmL−1 to 12.50μg mL−1 having correlation coefficient of 0.9980 (r2) with 1.24 µg mL−1 limit of detection and 4.15 µg mL-1 limit of quantification. The sensor exhibited the superb sensitivity for the detection of (SLM) with reproducibility of 3.19% relative standard deviation (RSD). The proposed method was further effectively applied for the analysis of SLM in pharmaceutical formulation with a recovery of 99.50 % to 100.73 %.

KEYWORDS: Nanocomposite, Sulfamoxole, Polypyrrole, Glassy Carbon Electrode, Voltammetric Sensor.