Carbon Nanotube-Based Bioanalytical Sensors

Wednesday, 31 May 2017: 14:00
Grand Salon A - Section 4 (Hilton New Orleans Riverside)
D. A. Heller (Weill Cornell Medicine, Cornell University), P. V. Jena (Memorial Sloan Kettering Cancer Center), T. V. Galassi (Weill Cornell Medicine, Cornell University), R. M. Williams, J. Budhathoki-Uprety (Memorial Sloan Kettering Cancer Center), R. E. Langenbacher (Weill Cornell Medical College, Cornell University), D. Roxbury, Y. Shamay, J. Shah, R. Frederiksen (Memorial Sloan Kettering Cancer Center), C. P. Horoszko (cornell), and J. D. Harvey (Weill Cornell Medicine, Cornell University)
The real-time and spatially-resolved detection and identification of analytes in biological media present important goals for next-generation nanoscale probes and sensors. To this end, we employ the intrinsic near-infrared fluorescence of single-walled carbon nanotubes which is photostable yet sensitive to the immediate environment. To build biomedical technologies that employ carbon nanotube photoluminescence, a better understanding of the optical response, as well as new methods to measure it in biological systems, are needed. We have developed new imaging platforms to quantify nanotube emission, including a method to conduct photoluminescence excitation/emission spectroscopy on living samples. We synthesized carbon nanotube-based photoluminescent sensors to interrogate analytes and processes in living specimens, including mammalian cells, 3D tumor spheroids, and whole organisms.