In the past decade, two-dimensional (2D) atomic crystals have stimulated great interest in the electronic device community for their interesting physics and diverse applications. With the rapid growing market of wearable electronics and internet-of-things (IoTs), flexible nanoelectronics with high operation speed and low power consumption has become one of the most researched topics. In this regard, 2D atomic van der Waals crystals has emerged as promising candidates for such applications owing to their compelling capabilities including ultimate thickness scalability, superior mechanical flexibility and highly tunable electronic performance. We describe state-of-the-art advancements in 2D flextronics based on chemical vapor deposition (CVD) monolayer graphene, CVD monolayer MoS₂, and few-layer black phosphorus with specific emphasis on radio frequency (RF) applications.