Proton exchange membrane(PEM) fuel cells generate power by hydrogen oxidation reaction at anode and oxygen reduction reaction at cathode(ORR). They hold the potential for replacing internal combustion engine for powering automotive vehicle in future while producing zero emission. However, the broad application of PEM fuel cells has been limited by their high cost due to the Pt catalysts used on both anode and cathode. Platinum-nickel (Pt-Ni) octahedral based nanomaterials represent an emerging class of highly active catalysts for oxygen reduction reaction (ORR) in fuel cells, but suffered from stability. In this talk, we present our recent progress in creating alloy structures that can not only significantly enhance the catalytic activity of Pt-Ni based octahedral but also exhibit great stability in both RDE and MEA tests.